OneSampleProportion.NIS: One sample proportion test for Non-inferiority/Superiority In TrialSize: R functions in Chapter 3,4,6,7,9,10,11,12,14,15

Description

Ho: p-p0 ≤ margin

Ha: p-p0 > margin

if margin >0, the rejection of Null Hypothesis indicates the true rate is superior over the reference value p0;

if margin <0, the rejection of the null hypothesis implies the true rate is non-inferior against the reference value p0.

Usage

 `1` ```OneSampleProportion.NIS(alpha, beta, p, delta, margin) ```

Arguments

 `alpha` significance level `beta` power = 1-beta `p` the true response rate `delta` delta=p-p0 the difference between the true response rate of a test drug and a reference value p0 `margin` the superiority or non-inferiority margin

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

Examples

 ```1 2``` ```Example.4.1.4<-OneSampleProportion.NIS(0.025,0.2,0.5,0.2,-0.1) Example.4.1.4 ```

TrialSize documentation built on May 30, 2017, 7:18 a.m.