Description Usage Arguments References Examples
View source: R/TwoSampleCrossOver.Equivalence.R
Ho: |margin| ≥ delta Ha: |margin| < delta
This test is whether the test drug is equivalent to the control in average if the null hypothesis is rejected at significant level alpha
1 | TwoSampleCrossOver.Equivalence(alpha, beta, sigma, delta, margin)
|
alpha |
significance level |
beta |
power = 1-beta |
sigma |
standard deviation in crossover design |
delta |
the superiority or non-inferiority margin |
margin |
margin=μ_2-μ_1 the true mean difference between a test mu2 and a control mu1 |
Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003
1 2 | Example.3.3.4<-TwoSampleCrossOver.Equivalence(0.05,0.1,0.2,0.25,-0.1)
Example.3.3.4 # 8
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