TwoSampleCrossOver.NIS: Two Sample Crossover Design Test for...

In TrialSize: R Functions for Chapter 3,4,6,7,9,10,11,12,14,15 of Sample Size Calculation in Clinical Research

Description

Ho: |margin| ≥ delta Ha: |margin| < delta

if delta >0, the rejection of Null Hypothesis indicates the superiority of the test over the control;

if delta <0, the rejection of the null hypothesis implies the non-inferiority of the test against the control.

Usage

TwoSampleCrossOver.NIS(alpha, beta, sigma, delta, margin)

Arguments

alpha	significance level
beta	power = 1-beta
sigma	standard deviation in crossover design
delta	the superiority or non-inferiority margin
margin	margin=μ_2-μ_1 the true mean difference between a test mu2 and a control mu1

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

Examples

Example.3.3.4<-TwoSampleCrossOver.NIS(0.05,0.2,0.2,-0.2,-0.1)
Example.3.3.4 # 13

Example output

[1] 12.36511

TrialSize documentation built on July 8, 2020, 7:19 p.m.