Description Usage Arguments References Examples
View source: R/TwoSampleMean.Equivalence.R
Ho: |margin| ≥ delta Ha: |margin| < delta
This test is whether the test drug is equivalent to the control in average if the null hypothesis is rejected at significant level alpha
1 | TwoSampleMean.Equivalence(alpha, beta, sigma, k, delta, margin)
|
alpha |
significance level |
beta |
power = 1-beta |
sigma |
pooled standard deviation of two groups |
k |
k=n1/n2 Example: k=2 indicates a 1 to 2 test-control allocation. |
delta |
the superiority or non-inferiority margin |
margin |
margin=μ_2-μ_1 the true mean difference between a test mu2 and a control mu1 |
Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003
1 2 | Example.3.2.4<-TwoSampleMean.Equivalence(0.1,0.1,0.1,1,0.05,0.01)
Example.3.2.4 #107
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