TwoSampleMean.NIS: Two Sample Mean Test for Non-Inferiority/Superiority

In TrialSize: R Functions for Chapter 3,4,6,7,9,10,11,12,14,15 of Sample Size Calculation in Clinical Research

Two Sample Mean Test for Non-Inferiority/Superiority

Description

Ho: margin \le delta Ha: margin > delta

if delta >0, the rejection of Null Hypothesis indicates the superiority of the test over the control;

if delta <0, the rejection of the null hypothesis implies the non-inferiority of the test against the control.

Usage

TwoSampleMean.NIS(alpha, beta, sigma, k, delta, margin)

Arguments

alpha	significance level
beta	power = 1-beta
sigma	pooled standard deviation of two groups
k	k=n1/n2 Example: k=2 indicates a 1 to 2 test-control allocation.
delta	the superiority or non-inferiority margin
margin	margin=\mu_2-\mu_1 the true mean difference between a test mu2 and a control mu1

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

Examples

Example.3.2.4<-TwoSampleMean.NIS(0.05,0.2,0.1,1,-0.05,0)
Example.3.2.4 # 50

  

TrialSize documentation built on April 12, 2025, 2:01 a.m.