TwoSampleProportion.Equivalence: Two sample proportion test for equivalence

In TrialSize: R Functions for Chapter 3,4,6,7,9,10,11,12,14,15 of Sample Size Calculation in Clinical Research

Description

Ho: |p1-p2| ≥ margin

Ha: |p1-p2| < margin

The proportion of response p1 is equivalent to the reference drug p2 is the null hypothesis is rejected

Usage

TwoSampleProportion.Equivalence(alpha, beta, p1, p2, k, delta, margin)

Arguments

alpha	significance level
beta	power = 1-beta
p1	the mean response rate for test drug
p2	the rate for reference drug
k	k=n1/n2
delta	delta=p1-p2
margin	the superiority or non-inferiority margin

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

Examples

Example.4.2.4<-TwoSampleProportion.Equivalence(0.05,0.2,0.75,0.8,1,0.2,0.05)
Example.4.2.4

TrialSize documentation built on July 8, 2020, 7:19 p.m.