Description Usage Arguments References Examples

View source: R/TwoSampleProportion.NIS.R

Ho: * p1-p2 ≤ margin *
Ha: p1-p2 > margin

if margin >0, the rejection of Null Hypothesis indicates the true rate p1 is superior over the reference value p2;

if margin <0, the rejection of the null hypothesis implies the true rate p1 is non-inferior against the reference value p2.

1 | ```
TwoSampleProportion.NIS(alpha, beta, p1, p2, k, delta, margin)
``` |

`alpha` |
significance level |

`beta` |
power = 1-beta |

`p1` |
the mean response rate for test drug |

`p2` |
the rate for reference drug |

`k` |
k=n1/n2 |

`delta` |
delta=p1-p2 |

`margin` |
the superiority or non-inferiority margin |

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

1 2 | ```
Example.4.2.4<-TwoSampleProportion.NIS(0.05,0.2,0.65,0.85,1,0.2,0.05)
Example.4.2.4
``` |

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