TwoSampleProportion.NIS: Two sample proportion test for Non-Inferiority/Superiority

In TrialSize: R Functions for Chapter 3,4,6,7,9,10,11,12,14,15 of Sample Size Calculation in Clinical Research

Two sample proportion test for Non-Inferiority/Superiority

Description

Ho: p1-p2 \le margin Ha: p1-p2 > margin

if margin >0, the rejection of Null Hypothesis indicates the true rate p1 is superior over the reference value p2;

if margin <0, the rejection of the null hypothesis implies the true rate p1 is non-inferior against the reference value p2.

Usage

TwoSampleProportion.NIS(alpha, beta, p1, p2, k, delta, margin)

Arguments

alpha	significance level
beta	power = 1-beta
p1	the mean response rate for test drug
p2	the rate for reference drug
k	k=n1/n2
delta	delta=p1-p2
margin	the superiority or non-inferiority margin

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

Examples

Example.4.2.4<-TwoSampleProportion.NIS(0.05,0.2,0.65,0.85,1,0.2,0.05)
Example.4.2.4

TrialSize documentation built on April 12, 2025, 2:01 a.m.