TwoSampleSurvival.Equivalence: Test for two sample equivalence in exponential model for...

In TrialSize: R Functions for Chapter 3,4,6,7,9,10,11,12,14,15 of Sample Size Calculation in Clinical Research

Test for two sample equivalence in exponential model for survival data

Description

margin=lamda1-lamda2, the true difference of hazard rates between control group lamda1 and a test drug group lamda2

H0: |margin| >= delta

Ha: |margin| < delta

This test is whether the test drug is equivalent to the control in average if the null hypothesis is rejected at significant level alpha

Usage

TwoSampleSurvival.Equivalence(alpha, beta, lam1, lam2, k, ttotal, taccrual, gamma, margin)

Arguments

alpha	significance level
beta	power = 1-beta
lam1	the hazard rates of control group
lam2	the hazard rates of a test drug
k	k=n1/n2 sample size ratio
ttotal	Total trial time
taccrual	accrual time period
gamma	parameter for exponential distribution. Assume Uniform patient entry if gamma =0
margin	margin=lamda1-lamda2, the true difference of hazard rates between control group lamda1 and a test drug group lamda2

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

Examples

Example.7.2.4<-TwoSampleSurvival.Equivalence(0.05,0.2,1,1,1,3,1,0.00001,0.5)
Example.7.2.4

TrialSize documentation built on April 12, 2025, 2:01 a.m.