Description Usage Arguments References Examples
View source: R/TwoSampleSurvival.Equivalence.R
margin=lamda1-lamda2, the true difference of hazard rates between control group lamda1 and a test drug group lamda2
H0: |margin| >= delta
Ha: |margin| < delta
This test is whether the test drug is equivalent to the control in average if the null hypothesis is rejected at significant level alpha
1 | TwoSampleSurvival.Equivalence(alpha, beta, lam1, lam2, k, ttotal, taccrual, gamma, margin)
|
alpha |
significance level |
beta |
power = 1-beta |
lam1 |
the hazard rates of control group |
lam2 |
the hazard rates of a test drug |
k |
k=n1/n2 sample size ratio |
ttotal |
Total trial time |
taccrual |
accrual time period |
gamma |
parameter for exponential distribution. Assume Uniform patient entry if gamma =0 |
margin |
margin=lamda1-lamda2, the true difference of hazard rates between control group lamda1 and a test drug group lamda2 |
Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003
1 2 | Example.7.2.4<-TwoSampleSurvival.Equivalence(0.05,0.2,1,1,1,3,1,0.00001,0.5)
Example.7.2.4
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