Vaccine.CEM: Composite Efficacy Measure(CEM) for Vaccine clinical trials.

In TrialSize: R Functions for Chapter 3,4,6,7,9,10,11,12,14,15 of Sample Size Calculation in Clinical Research

Description

Let sij be the severity score associated with the jth case in the ith treatment group. μ_i=mean(s_{ij}), σ^2_i=var(s_{ij}).

H0: pT=pC and muT=muC

Ha: pT is not equal to pC and muT is not equal to muC

Usage

Vaccine.CEM(alpha, beta, mu_t, mu_c, sigma_t, sigma_c, pt, pc)

Arguments

alpha	significance level
beta	power=1-beta
mu_t	mean of treatment group
mu_c	mean of control group
sigma_t	standard deviation of treatment group
sigma_c	standard deviation of control group
pt	the true disease incidence rates of the nt vaccines
pc	the true disease incidence rates of the nc controls

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

Examples

Example.15.6.4<-Vaccine.CEM(0.05,0.2,0.2,0.3,sqrt(0.15),sqrt(0.15),0.1,0.2)
Example.15.6.4

TrialSize documentation built on July 8, 2020, 7:19 p.m.