Vaccine.ELDI | R Documentation |
If the disease incidence rate is extremely low, the number of cases in the vaccine group given the total number of cases is distributed as a binomial random variable with parameter theta.
Ho: \theta \ge \theta_{0}
Ha: \theta < \theta_{0}
Vaccine.ELDI(alpha, beta, theta0, theta, pt, pc)
alpha |
significance level |
beta |
power=1-beta |
theta0 |
the true parameter for binomial distribution. Theta0 is usually equal to 0.5 |
theta |
theta=disease rate for treatment group/(disease rate for treatment group + for control group) |
pt |
the true disease incidence rates of the nt vaccines |
pc |
the true disease incidence rates of the nc controls |
Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003
Example.15.6.2<-Vaccine.ELDI(0.05,0.2,0.5,1/3,0.001,0.002)
Example.15.6.2
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