Vitro.BE | R Documentation |
Consider 2 by 2 crossover design.
\zeta = \delta^2+sT^2+sR^2-thetaBE*max(\sigma_0^2,sR^2)
. sT^2=\sigma_{BT}^2+\sigma_{WT}^2
, sR^2=\sigma_{BR}^2+\sigma_{WR}^2
Ho: \zeta \ge 0
Ha: \zeta < 0
Vitro.BE(alpha, beta, delta, sigmaBT, sigmaBR, sigmaWT, sigmaWR, thetaBE)
alpha |
significance level |
beta |
power = 1-beta |
delta |
delta is the mean difference |
sigmaBT |
|
sigmaBR |
|
sigmaWT |
|
sigmaWR |
|
thetaBE |
here thetaBE=1 |
Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003
Example.10.5<-Vitro.BE(0.05,0.2,0,0.5,0.5,0.5,0.5,1)
Example.10.5
# n=43 Vitro.BE reach 0
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