WilliamsDesign.NIS: Williams Design test for Non-inferiority/Superiority

In TrialSize: R Functions for Chapter 3,4,6,7,9,10,11,12,14,15 of Sample Size Calculation in Clinical Research

Williams Design test for Non-inferiority/Superiority

Description

H0: \mu_1-\mu_2 \le margin

Ha: \mu_1-\mu_2 > margin

Usage

WilliamsDesign.NIS(alpha, beta, sigma, sequence, delta, margin)

Arguments

alpha	significance level
beta	power = 1-beta
sigma	standard deviation in crossover design
sequence	total sequence number
delta	the superiority or non-inferiority margin
margin	margin=\mu_1-\mu_2

References

Chow SC, Shao J, Wang H. Sample Size Calculation in Clinical Research. New York: Marcel Dekker, 2003

Examples

Example.4.5.4<-WilliamsDesign.NIS(0.05,0.2,0.75^2,6,0.2,0.05)
Example.4.5.4

TrialSize documentation built on April 12, 2025, 2:01 a.m.